Mechanism for the enhancement of paracellular and transcellular permeability by absorption promoters.
نویسندگان
چکیده
منابع مشابه
Lipopolysaccharide-induced caveolin-1 phosphorylation-dependent increase in transcellular permeability precedes the increase in paracellular permeability
BACKGROUND Lipopolysaccharide (LPS) was shown to induce an increase in caveolin-1 (Cav-1) expression in endothelial cells; however, the mechanisms regarding this response and the consequences on caveolae-mediated transcellular transport have not been completely investigated. This study aims to investigate the role of LPS-induced Cav-1 phosphorylation in pulmonary microvascular permeability in p...
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Neutrophil diapedesis: paracellular or transcellular?
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متن کاملPhosphorylation of caveolin-1 regulates oxidant-induced pulmonary vascular permeability via paracellular and transcellular pathways.
RATIONALE Oxidants are important signaling molecules known to increase endothelial permeability, although the mechanisms underlying permeability regulation are not clear. OBJECTIVE To define the role of caveolin-1 in the mechanism of oxidant-induced pulmonary vascular hyperpermeability and edema formation. METHODS AND RESULTS Using genetic approaches, we show that phosphorylation of caveoli...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1987
ISSN: 0916-1139
DOI: 10.2133/dmpk.2.573